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The present invention relates to a particular salt form of simvastatin, which is a 3-hydroxymethylglutaryl-coenzyme A HMG-CoA reductase inhibitor. Insbesondere betrifft die Erfindung eine spezielle kristalline hydratisierte Form des Calciumsalzes der offenen Simvastatin-Dihydroxy-Säure, die hierin als Verbindung I bezeichnet wird. In particular, the invention relates to a particular crystalline hydrated form of the calcium salt of the open referred to herein as compound I simvastatin dihydroxy-acid. For several decades, it is known that elevated blood cholesterol is a major risk factor for coronary heart disease CHD , and many studies have shown that the risk of CHD cases can be reduced by lipid-lowering therapy.
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DE4417640A1 - Ointment base hydrocarbon base with Vaselinestruktur - Google Patents

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DEA1 - Ointment base hydrocarbon base with Vaselinestruktur - Google Patents

Die Erfindung betrifft Salbengrundlagen auf Kohlenwasserstoffbasis mit Vaselinestruktur. The invention relates ointment bases hydrocarbon base with Vaselinestruktur. In der Pharmazie sind, zum Teil schon seit langem, Salbengrundlagen auf Kohlenwasserstoffbasis bekannt, deren am häufigsten verwendete wahrscheinlich Vaseline ist. Vaseline ist ein Produkt der Erdöldestillation und kommt in unterschiedlicher Qualität in den Handel. Vaseline is a product of petroleum distillation and comes in varying quality on the market. Vaseline besteht aus einem Gemisch im wesentlichen gesättigter und im wesentlichen geradkettiger Kohlenwasserstoffe bis hin zum Dotriacontan zusammen mit geringen Anteilen olefinischer Kohlenwasserstoffe mit etwa 10 bis 18 C-Atomen. Vaseline consists of a mixture essentially saturated and linear hydrocarbons substantially up to the dotriacontane together with small amounts of olefinic hydrocarbons having from about 10 to 18 carbon atoms.
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All сomments (7)

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